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Geisinger Medical Laboratories Test Catalog
PLATELET FUNCTION ASSAY PANEL |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB3490 Geisinger Epic ID: 119767 | |
SPECIMEN COLLECTION |
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Specimen type: |
Whole blood | |
Preferred collection container: |
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Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
Lavender-top (K2 EDTA) microcollection tube
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Specimen required: |
2.7 mL blue-top (3.2% sodium citrate) tube AND 3mL lavender-top (K2 EDTA) tube. | |
Special notes: |
Collect BOTH blue-top and lavender-top tube. BOTH are required. Perform venipuncture with no trauma. If blood is drawn from indwelling catheter, flush with 5mL of saline and discard the first 5 mL of blood collected to avoid contaminating sample with tissue thromboplastin or heparin. If using a butterfly needle setup for collection, draw a discard blue-top tube first to remove air from tubing. Specimen must be collected with a needle diameter no smaller than a 21 gauge. This test is offered at a limited number of performing laboratories and may only be collected and performed at testing sites (see below). Send blood specimen to lab as soon as possible after collection. Do not transport specimens via pneumatic tube or courier. |
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Patient preparation: |
Patient's hematocrit must be >30% or <55% and platelet count must be >50,000/uL. Patient should not be on any medication known to affect platelet function. Low hematocrit (<35%) and/or low platelet count (50,000–150,000/uL) may affect results, but testing will still be completed. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Do not centrifuge, refrigerate or freeze blue-top specimens. Do not ship specimen through the pneumatic tube system or by courier. | |
Transport temperature: |
Room temperature | |
Specimen stability: |
Specimen is stable for up to four hours | |
Rejection criteria: |
Clotted specimen. Hematocrit <30% or Hematocrit >55%. Platelet count <50,000/µL. Overfilled or underfilled tubes. Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
89-193 seconds Collagen/EPI 64-120 seconds Collagen/ADP |
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Interpretation guide: |
Prolongation (EPI >193 sec and ADP >120 sec) of closure time indicates decreased platelet function, low HCT, or low platelets (PLT). Aspirin-like drugs prolong EPI cartridge only. Von Willebrand disease, intrinsic platelet dysfunction, and some other non-aspirin drugs prolong EPI and ADP. Shortened closure times (EPI<89 sec & APD <64 sec) are associated with increased PLT number or function. The PFA-100® is insensitive to thienopyridine drugs (clopidogrel). | |
CPT code(s): |
85576 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
PFA100(EPI/COLL), HCT, PLT, PFA100 (ADP/COLL), if indicated | |
Methodology: |
Simulated platelet adhesion and aggregation in whole blood using a high-shear testing system |
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Synonyms: |
PFA, PFA 100, PLATELET FUNCTION SCREEN PFASCR
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Clinical significance: |
The platelet function assay panel is used to screen patients suspected of having a platelet dysfunction that may be caused by intrinsic platelet defects, von Willebrand disease, or exposure to platelet inhibiting agents. Additional platelet function testing may be indicated with abnormal results. | |
Doctoral Director(s:) |
Mary Dhesi MD | |
| Review Date: | 04/04/2023 | |
Performing Locations
Geisinger Wyoming Valley Medical Center