Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  


Sunquest Test Code:
RNPSM      Geisinger Epic Procedure Code: 86235.04         Geisinger Epic ID: 15175

Specimen type:
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
0.5 mL serum; minimum 0.2 mL

Specimen processing instructions:
Allow to clot. Centrifuge and submit 0.5 mL serum. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.
Specimen stability:
Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

Interpretation guide:
Normal range/negative < 20.0
Weak Positive 20.1 - 39.9
Moderate Positive 40.0 - 80.0
Strong Positive > 80.0
CPT code(s):
86235 x2
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
RNP Antibody, SM Antibody
Enzyme-Linked Immunosorbent Assay (ELISA)
SM/RNP Antibodies, RNP/SM Antibodies
ENA (anti-Extractable Nuclear Antigen)
Smith antibody, riboncleoprotein antibody
Clinical significance:
Positive RNP and SM antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of systemic lupus erythematosus (SLE) and other related connective tissue diseases. SM antibodies are highly specific for SLE and are detected in appproximately 15% of patients with SLE.
Doctoral Director(s:)
Stacy Kenyon, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC    
Review Date: 10/24/2018

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: Tuesday, Friday, 1st shift
Performed stat? No
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