You are here: Geisinger Medical
Laboratories > Test
Catalog
Geisinger Medical Laboratories Test Catalog
RNP AND SM ANTIBODIES |
||
Geisinger Epic Procedure Code: LAB3020
Geisinger Epic ID: 15175
|
||
SPECIMEN COLLECTION |
||
Specimen type: |
Serum | |
Preferred collection container: |
||
Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
|
|
Specimen required: |
0.5 mL serum; minimum 0.2 mL | |
| SPECIMEN PROCESSING |
||
Specimen processing instructions: |
Allow to clot. Centrifuge and submit 0.5 mL serum. | |
Transport temperature: |
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable. | |
Specimen stability: |
Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months. | |
Rejection criteria: |
Specimen stability exceeded; specimen grossly hemolyzed. | |
TEST DETAILS |
||
Reference interval: |
RNP: Negative <5 U/mL Sm: Negative <7 U/mL |
|
Interpretation guide: |
RNP: Negative <5 U/mL Equivocal 5-10 U/mL Positive >10 U/mL Sm: Negative <7 U/mL Equivocal 7-10 U/mL Positive >10 U/mL |
|
CPT code(s): |
86235 x2 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
RNP Antibody, SM Antibody | |
Methodology: |
Enzyme Immunoassay (EIA) |
|
Synonyms: |
SM/RNP Antibodies, RNP/SM Antibodies, RNPSM Smith antibody, riboncleoprotein antibody
|
|
Clinical significance: |
Positive RNP and SM antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of systemic lupus erythematosus (SLE) and other related connective tissue diseases. SM antibodies are highly specific for SLE and are detected in appproximately 15% of patients with SLE. | |
Doctoral Director(s:) |
Hoi-Ying Elsie Yu PhD, DABCC, FADLM | |
| Review Date: | 12/13/2022 | |