Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

HEPARIN AB, ANTI-PLATELET FACTOR 4

ORDERING INFORMATION:
Sunquest Test Code:
HITGAM      Geisinger Epic Procedure Code: 86022.09         Geisinger Epic ID: 31824

SPECIMEN COLLECTION
Specimen type:
Serum (preferred) or sodium citrate plasma also acceptable.
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
2.7 mL blue-top (3.2% sodium citrate) tube
Specimen required:
0.5 mL aliquot serum (preferred) or plasma; minimum 0.2 mL
Special notes:
For same day testing, specimen must be received in Immunology Laboratory by noon. Specimens received after that time will be tested on the next testing day.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow serum to clot. Centrifuge and submit 0.5 mL aliquot of serum (preferred) or plasma. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.
Specimen stability:
Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

TEST DETAILS
Reference interval:
<0.400
Critical values/courtesy alerts:
> 0.400
CPT code(s):
86022
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Polyspecific (IgG, A, and M) antibody to platelet factor 4.
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
Synonyms:
Heparin-induced thrombocytopenia
Ab to platelet factor 4
HIT, Anti-platelet factor 4, Anti-PF4
HAT, heparin-induced thrombocytopenia GAM
Heparin-associated antibody
Clinical significance:
Heparin-induced thrombocytopenia (HIT) is the most common form of drug-induced thrombocytopenia and can develop in up to 5% of patients treated with heparin. A presumptive diagnosis of HIT can be based on a > 50% reduction in platelet count more than 5 days after initiation of heparin therapy, a platelet count <150,000/uL or the development of thromboembolic complications.
Doctoral Director(s:)
Stacy Kenyon, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC    
Review Date: 10/31/2018

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: Daily, 1st shift
Performed stat? No
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