Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

FACTOR VII (7) CLOTTING ACTIVITY

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2256         Geisinger Epic ID: 7122

SPECIMEN COLLECTION
Specimen type:
Platelet-free plasma
Preferred collection container:
Alternate Collection Container:
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
Specimen required:
1 mL aliquot plasma.
Special notes:
Do not draw blood from a heparinized line. Avoid contaminating the sample with tissue thromboplastin or heparin. Venipuncture must be performed with no trauma. If blood is drawn from an indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected. If drawn with a butterfly setup, draw a discard first to remove air from tubing.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge the citrated blue-top tubes as soon as possible (within 60 minutes) at designated time and speed to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, remove 1 mL of plasma and transfer to a plastic polypropylene aliquot tube and label with patient's name and a second patient identifier (e.g., date of birth, medical record number). Freeze upright and transport on dry ice. 
Transport temperature:
Frozen.
Specimen stability:
Frozen: -20°C for 30 days, -70°C for 6 months. Room temperature: 4 hours.
Rejection criteria:
Clotted specimen. Stability limits exceeded. Overfilled or underfilled tubes. HCT > 55. HCT > 55 requires rejection, reorder in LIS, and recollection with proper adjustment of anticoagulant. Indications of thaw in transit are sample on slant in aliquot tube or in lid of tube. These samples will be run but will receive a comment of interpret results with caution as thawing suspected.

TEST DETAILS
Reference interval:
65-135%
Additional information:
Do not store plasma at 2-8°C due to Factor VII potential activation. Anticoagulation Impact on Coagulation Tests
CPT code(s):
85230
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Factor VII Assay.
Methodology:
Mechanical Clot-Based
Synonyms:
Factor VII, Factor 7, FA7
Clinical significance:
Factor 7 is a blood protein involved in blood clot formation. It is made in the liver, is vitamin K dependent, and has the shortest half life of the clotting factors. Low levels can cause a bleeding disorder. Factor 7 levels are decreased in patients with congenital deficiencies (rare), acquired factor 7 antibodies (rare), vitamin K antagonist (warfarin), vitamin K deficiency from poor oral intake, malabsorption, or improper metabolism (hemorrhagic disease of newborn, cholestasis, certain antibiotic therapy), liver disease, fibrinolysis or DIC. Testing is utilized in bleeding patients that have an unexplained prolonged PT.
Doctoral Director(s:)
Michelle Grant DO    
Review Date: 01/03/2021

Performing Locations

Geisinger Medical Center

Performing laboratory: Coagulation
Technical Lead: Margaret Knowles-Tuchman
Frequency: Daily, all shifts. Performed stat with Pathologist approval.
Performed stat? Yes
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