Dr. Zongming (Eric) Chen

Dr. Eric ChenZONGMING (ERIC) CHEN,M.D., Ph.D.
Director, Immunohistochemistry

100 North Academy Avenue
Danville, PA 17822-1920
1 800 695 6491

Dr. Chen is an Associate of Geisinger Medical Laboratories at Geisinger Medical Center, where he serves as the Director of Immunohistochemistry.

Education:

He received his M.D. from Zhejiang University School of Medicine, China. He also holds a Ph.D. in microbiology and immunology from the University of Minnesota. Dr. Chen received his pathology residency training in anatomic and clinical pathology at Washington University at St. Louis and completed postdoctoral fellowships in surgical pathology at Washington University at St. Louis and in GI and liver pathology fellowship at Johns Hopkins Medical Institutions at Baltimore

Certifications:

Dr. Chen is board certified in anatomic and clinical pathology.

Professional Affiliations:

College of American Pathologists (CAP)
American Society for Clinical Pathology (ASCP)
United States and Canadian Academy of Pathology (USCAP)

Research Interests:

Gastrointestinal and liver pathology and noncervical gynecologic pathology.

Publications in Peer-Reviewed Journals:

Wang HL, Kim CJ, Koo J, Zhou W, Choi EK, Arcega R, Chen ZE, Wang H, Zhang L, Lin F. Practical immunohistochemistry in neoplastic pathology of the gastrointestinal tract, liver, biliary tract, and pancreas. Arch Pathol Lab Med. 2017; 141:155-1180.

Pineda JJ, Diehl DL, Miao CL, Johal AJ, Khara HS, Bhanushali A and Chen Z. EUS-guided liver biopsy provides diagnostic samples comparable with those via the percutaneous or transjugular route. Gastrointest Endosc. 2016; 88:360-365.

Shi J, Liu H, Ma XJ, Chen Z, He MX, Luo Y, Lin F. Ribonucleic Acid In Situ Hybridization Is a More Sensitive Method Than Immunohistochemistry in Detection of Thyroid Transcription Factor 1 and Napsin A Expression in Lung Adenocarcinomas. Arch Pathol Lab Med. 2016; 140(4):332-349.

Diehl DL, Johal AS, Khara HS, Stavropoulos SN, Al-Haddad M, Ramesh J, Varadarajulu S, Aslanian H, Gordon SR, Shieh FK, Pineda-Bonilla JJ, Dunkelberger T, Gondim DD, Chen EZ. Endoscopic ultrasound-guided liver biopsy: a multicenter experience. Endosc Int Open. 2015; 3(3):E210-5.

Kim AH, Shellenberger MJ, Chen ZM, Li J. Case report of gastric outlet obstruction from metastatic lobular breast carcinoma. BMC Gastroenterol. 2015; 15:120.

Lin F, Chen ZM, Wang HL. Utility of immunohistochemistry in the pancreatobiliary tract.. Arch Pathol Lab Med. 2015; 139(1):24-38.

Chen ZM, Lin F. Application of immunohistochemistry in gastrointestinal and liver neoplasms: new markers and evolving practice.. Arch Pathol Lab Med. 2015; 139(1):14-23.

Lin F, Chen Z. Standardization of diagnostic immunohistochemistry: literature review and geisinger experience. Arch Pathol Lab Med. 2014; 138(2):1564-1577.

Lai JP, Chen ZM, Lok T, Chan OT, Himmelfarb E, Zhai Q, Lin F, Wang HL. Immunohistochemical stains of proliferating cell nuclear antigen, insulin-like growth factor 2 and clusterin help distinguish malignant from benign liver nodular lesions. J Clin Pathol. 2014; 67(6):464-469.

Lin F, Shi J, Zhu S, Chen Z, Li A, Chen T, Wang HL, Liu H. Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. Arch Pathol Lab Med. 2014; 138:1015-1026.

Heller JJ, Schjerven, H, Li S, Lee A, Qiu J, Chen Z, Smale ST, Zhou L. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zink finger transcription factor Ikaros. J Immunol. 2014; 193(8):3934-3946.

Garcia-Carracedo D, Chen ZM, Qiu W, Huang AS, Tang SM, Hruban RH, Su GH. PIK3CA mutations in mucinous cystic neoplasms of the pancreas. Pancreas. 2014; 43(2):245-249.

Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, Chen Z, Angarone M, Weissleder R Khazaie K, Battett TA. Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis. Inflamm Bowel Dis. 2013; 19(7):1339-45.

Matkowskyj KA, Chen Z, Rao MS, Yang GY. Dysplastic lesions in inflammatory bowel disease: molecular pathogenesis to morphology. Arch Pathol Lab Med. 2013; 137(3):338-50.

Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen Z, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K. PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages and epithelial cells in colitis-induced cancer. Clin Cancer Res. 2013; 19(9):2342-2354.

Gurel S, Narra V, Elsayes KM, Siegel CL, Chen ZE, Brown JJ. Subtypes of renal cell carcinoma: MRI and pathological features. Diagn Interv Radio. 2013; 19(4):304-311.


Other Publications:

Chen ZE, Liu H, Wilkerson ML. Archives Applied – Evolving Practices of IHC in Breast, Genitourinary, Gastrointestinal, and Liver Pathology. College of American Pathologists Online CME, Self-Assessment Module, 2015.

Abstracts, Posters, and Other Presentations:

Chen ZE, Bitting A, Lin F. Assessment of PD-L1 expression in tumor microenvironment of mismatch repair deficient colon cancer: comparing two antibody clones, SP142 vs. SP263. Poster presentation United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.

Chen ZE, Bitting A, Kip NS, Lin F. Quality Assurance Aspects of implementing BRAFV600E Immunohistochemistry (IHC) Assay in Universal Lynch Syndrome Screening (ULS) for Colorectal Cancer (CRC): A Single Institution Experience. Abstract United States and Canadian Academy of Pathology, March 12-16, 2016, Seattle, Washington.

Chen Z, Li H, Kip NS, Lin F. Detection of mismatch repair protein (mmr) loss by immunohistochemistry (IHC) in colorectal adenomas from young patients: an appraisal of its utility in lynch syndrome screening. Abstract/Presentation USCAP Annual Meeting, Seattle, WA, March 2016.

Zhou W, Koo J, Wang HL, Liu H, Chen Z, Lin F. Diagnostic utility of clusterin immunostaining in differentiating hepatocellular carcinoma from tumors of other origins. Abstract/Presentation USCAP Annual Meeting, Seattle, WA, March 2016.

Yin H, Zhu S, Zelonis M, Snyder D, Kip NS, Chen ZE. Patchy high frequency of nonspecific abnormal signals (background noise): a common pitfall in interpretation of ALK FISH results. Abstract USCAP Annual Meeting, Boston, March 12-18, 2016.

Rahm AK, Kip NS, Guha S, Fan A,, Kaspar HG, Williams JL, Gogoi R, Chen Z, Davis D, Williams MS. Coordinating laboratory and clinical data to incorporate endometrial tumor testing into the Universal Lynch Syndrome Screening program at Geisinger Health System. National Society of Genetic Counselors Annual Education Conference, Pittsburgh, PA, October 20-24, 2015.

Rahm AK, Kip NS, Guha S, Fan A,, Kaspar HG, Williams JL, Gogoi R, Chen Z, Davis D, Williams MS. Evaluation of Colorectal and Endometrial Cancer Screening Programs to Optimize Universal Lynch Syndrome Screening at Geisinger Health System. Poster American Society of Human Genetics Annual Meeting, Baltimore, MD, October 6-10, 2015.

Chen Z. Quality management of IHC in diagnostic oncological pathology. Presentation Pathology” Presented In The 1st China-Us Diagnostic Oncological Pathology Summit , Beijing, China, October 17, 2015.

Chen Z. New IHC markers useful in diagnosis of colorectal cancer. Speaker 1st CAPA Diagnostic Pathology Course, Flushing, New York, August 22, 2015.

Yin H, Zhu S, Zelonis M, Snyder D, Kip NS, Chen ZM. Insufficient formalin fixation can negatively affect detection of ALK rearrangement in lung cancer by fluorescence in situ hybridization (FISH). Presentation United States &Canadian Academy of Pathology, Boston, Massachusetts, March 17-21, 2015.

Lin F, Shi J, Chen Z, Liu H. Impact of tissue decalcification on immunohistochemical detection of select markers for carcinoma of unknown origin. Abstract/Presentation USCAP Annual Meeting, Boston, MA, March 2015.

Chen Z, Yin H, Li J, Zhu S, Lin F. Improving HER2 assessment in gastroesophageal junction (GEJ) and gastric adenocarcinoma (GADC): lessons from concurrent immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) study of 117 specimens. Abstract/Presentation USCAP Annual Meeting, Boston, MA, March 2015.

Lin F, Shi J, Chen ZM, Liu H. Immunohistochemical evaluation of c-Myc expression in carcinomas from various organs. Presentation CAP Annual Meeting, Chicago, IL, September 7-10, 2014.

Pineda-Bonilla JJ, Johal Amitpal, Maio Chuan, Khara HS, Chen ZM, Li J, Prichard JW, Diehl DL. EUS-guided liver biopsy provides diagnostic samples with quantitative yields superior to percutaneous or transjugular routes. Presentation American Gastroenterological Association Digestive Disease Week, Chicago, IL, May 3-6, 2014.

Pineda-Bonilla, JJ, Kim, A, Johal A, Miao CL, Khara HS, Li JH, Prichard, JW, Chen ZM, Diehl DL . Assessment of hepatic steatosis by computerized image analysis using whole slide scanning technology. Presentation American Gastroenterological Association Digestive Disease Week, Chicago, IL, May 3-6, 2014.

Chen ZM, Liu H, Lin F. Loss of PAX2 nuclear expression: a useful diagnostic feature for in situ and invasive endocervical adenocarcinoma. Presentation USCAP Annual Meeting, San Diego, CA, March 1-7, 2014.

Zhu S, Lin F, Chen ZM, . Low frequency of HER2 overexpression and amplification detected by immunohistochemical stain and dual chromogenic in situ hybridization (CISH) in pancreatic ductal adenocarcinoma. Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Chen ZM, Zhu S, Liu H, Lin F. Loss expression of CDX2 and CK20 in medullary carcinoma of the colon is associated with poor survival. Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Chen ZM, Lin X, Wang M, Lin F, Rao S. Regenerative nodule-like intrahepatic cholangiocarcinoma: is it a morphology for in situ cholangioarcinoma arising in cirrhotic liver? . Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Zhu S, Lin F, Chen ZM. Mitosis-specific marker PHH3 immunostain is a more sensitive and efficient method to evaluate the mitotic activity in gastrointestinal stromal tumor (GIST). Presentation USCAP Annual Meeting , Baltimore, MD, March 2-8, 2013.

 

Textbook Chapters:

Chen ZM, LI J, Lin F. Lower gastrointestinal tract. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 2nd ed. Lin F, Prichard JW, Liu H, Wilkerson M, Chen ZM, eds. New York: Springer; 2015: 543-556.

Chen ZM, Prichard J, Lin F. Liver, Bile Ducts and Gallbladder. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 2nd ed. Lin F, Prichard JW, Liu H, Wilkerson M, Chen ZM, eds. New York: Springer; 2015: 503-524.

Chen ZM, Lin F. Overview of Predictive Biomarkers and Integration of IHC into Molecular Pathology. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 2nd ed. Lin F, Prichard JW, Liu H, Wilkerson M, Chen ZM, eds. New York: Springer; 2015: 91-104.

Lin F, Prichard J, Bitting A, Shi J, Liu H, Wilkerson M, Chen Z. Geisinger immunohistochemical antibodies and staining protocols. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions. 2nd ed.. Lin F, Prichard JW, Liu H, Wilkeson M, Chen ZM, eds. New York: Springer; 2015: 39-56.

 

Locations  |    Search  |    Site Map |   Contact Us

©2000-2019 Geisinger Health System.   All rights reserved.