Dr. Zongxian Cao

Anatomic Pathology, Clinical Pathology

Geisinger Wyoming Valley Medical Center
1000 East Mountain Boulevard
Wilkes-Barre, PA 18711

Dr. Cao is an associate of Geisinger Medical Laboratories at Geisinger Wyoming Valley Medical Center. He is also an assistant professor at Geisinger Commonwealth School of Medicine.


Dr. Cao received his medical degree from Shandong Medical University, Ji'nan, Shandong, China. He also holds a master’s degree from Beijing Medical University, Beijing, China, and a PhD in Cancer Cell Biology from West Virginia University, Morgantown, West Virginia.  Dr. Cao completed his residency training in anatomic and clinical pathology at the University of Missouri-Columbia Program and fellowship training in GI pathology at Icahn School of Medicine at Mount Sinai, New York.


Dr. Cao is board certified in anatomic and clinical pathology.

Professional Affiliations:

Rodger C. Haggitt Gastrointestinal Pathology Society (GIPS)
United States and Canadian Academy of Pathology (USCAP)
College of American Pathologists (CAP)
American Society for Clinical Pathology (ASCP)

Research Interests

Dr. Cao is board certified in anatomic and clinical pathology. His areas of interest include gastrointestinal, liver, and thoracic pathology. 

Recent Academic Activity

Publications in Peer-Reviewed Journals:

Omer DM, Dozier J, Cao Z, Zhu H, McCain DA. A case report on a large, peduncular intra-abdominal hepatocellular carcinoma extending into the retroperitoneum. Clin Case Rep. 2021; 9(3): 1288-1291,

Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Boulares AH, Auwerx J, Gao B, Pacher P. PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. J Hepatol. 2017; 66(3): 589-600,

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G. Hybrid inhibitor of peripheral cannabinoid 1 receptors and inducible nitric oxide synthase for the treatment of liver fibrosis. JCI Insight. 2016; 1(11): e-87336,

Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdélyi K, Hao E, Holovac E, Haskó G, Cravatt BF, Nomura DK, Pacher P. Monoacylglycerol Lipase Controls Endocannabinoid and Eicosanoid Signaling and Hepatic Injury in Mice. Gastroenterology. 2013; 144(4): 808-817,

Cao Z, Dhupar R, Cai C, Li P, Billiar TR, Geller DA. A Critical Role for IFN Regulatory Factor 1 in NKT Cell-Mediated Liver Injury Induced by a-Galactosylceramide. J Immunol. 2010; 185: 2536-2543,

Cao Z, Yuan Y, Jeyabalan G, Du Q, Tsung A, Geller DA, Billiar TR. Preactivation of NKT cells with a-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor. Liver Physiol. 2009; 297: G249-G258,

Cao Z, Liu LZ, Dixon DA, Zheng JZ, Chandran B, Jiang BH. Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. Cell Sgnal. 2007; 19(7): 1524-1553,

Cao Z, Fang J, Xia C, Shi X, Jiang BH. Trans-3,4,5'-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1a and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells. Clin Cancer Res. 2004; 10: 5253-5263,

Abstracts, Posters, and Other Presentations:

Cao Z, Cai Z, Ballentine SJ, Ambelil M, Polydorides AD, Zhu H, Ko HM, Liu QQ, Harpaz N. Targeted DNA Sequencing Reveals Distinct Mutational Profiles in Polypoid Zongxian Cao, MD, PhD Page 5 of 5 Dysplasia of IBD versus Matched Colorectal Adenomas. Abstract USCAP 2019 annual meeting, National Harbor, Maryland, March 16, 2019.

Cao Z, Esebua M, Rawlings A, and Layfield L. Mast cell infiltration and activation in the gallbladder wall: implications for the pathogenesis of functional gallbladder disorder in adult patients. Abstract USCAP 2018 annual meeting, Vancouver, Canada, March 21, 2018.

Cao Z, Jiang BH. p70S6K modulates the angiogenic effects of angiopoietin-1. Selected Platform Presentation The 2006 Miami Nature Biotechnology Winter Symposium, Miami, Florida, April 1, 2006.

Cao Z, Rajan S, Chuquilin-Arista M, Joel SI, Norregaard TV, Adelstein EH, and Miller DC. Primary CNS lymphoma complicating multiple sclerosis: a case report. Case Report ASCP 2015 Annual Conference, Long Beach, California, October 28, 2015.

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