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Geisinger Medical Laboratories Test Catalog
ISLET CELL ANTIBODY SCREEN W/REFLEX TO TITER |
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Geisinger Epic Procedure Code: LAB1757
Geisinger Epic ID: 34839
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SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Specimen required: |
2 mL aliquot of serum; minimum 0.5 mL. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Allow to clot. Centrifuge 10 minutes at 3000 rpm. | |
Transport temperature: |
Refrigerated (preferred) or frozen. | |
Specimen stability: |
Room Temperature: 2 days. Refrigerated: 2 weeks. Frozen: 6 months. | |
Rejection criteria: |
Stability limits exceeded. Grossly hemolyzed, lipemic or icteric specimens are not acceptable. Specimens received at testing laboratory (Quest) at room temperature are not acceptable. | |
TEST DETAILS |
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Reference interval: |
Accompanies report. Islet cell Ab screen ngeative. Islet cell Ab titer < 125 JDF units. | |
Additional information: |
If the screen is positive, the test will reflex to a titer at an additional charge. | |
CPT code(s): |
86341 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Indirect Immunofluorescence |
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Synonyms: |
Quest test code 36741, ANTI-ISLET CELL ANTIBODY ISLAB
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Clinical significance: |
Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process. | |