Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

EBV-EBNA

ORDERING INFORMATION:
Sunquest Test Code:
EBNAAB      Geisinger Epic Procedure Code: 86664         Geisinger Epic ID: 7431

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
0.5 mL serum; minimum 0.2 mL

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge and submit 0.5 mL serum. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) or frozen specimen also acceptable.
Specimen stability:
Room temperature: 8 hours. 2-8°C: 96 hours. Frozen: 6 months
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

TEST DETAILS
Interpretation guide:
Unit value
Result
Interpretation
< 18.0 u/mL Negative Absence of detectable EBNA IgG antibodies. A negative result generally excludes past EBV infection. If exposure to Epstein-Barr virus is suspected despite a negative finding, a second sample should be collected and tested no less than one to two weeks later.
18.0 to 21.9 U/mL Equivocal Suggest a second sample be collected and tested one to two weeks later.
> 22.0 U/mL Positive Presence of detectable EBNA IgG antibodies. A positive result is indicative of past infection.
CPT code(s):
86664
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Antibody detection to EBNA.
Methodology:
Chemiluminescence
Synonyms:
EBNA, Epstein Barr IgG antibody to nuclear antigens
Epstein Barr Nuclear Antigen
EBV-EBNA
EBNA IgG Antibody, Epstein Barr Nuclear Antigen IgG
Clinical significance:
Epstein-Barr virus (EBV) is responsible for infectious mononucleosis (IM) and has also been implicated in Burkitt's lymphoma and nasopharyngeal carcinoma. EBV-NA (Epstein-Barr virus nuclear antigen) IgG antibodies appear during the convalescent phase of IM and remain present throughout life. A positive EBV-NA IgG antibody in a healthy individual indicates past immunological exposure to EBV.
Doctoral Director(s:)
Stacy Kenyon, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC    
Review Date: 10/31/2018

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: Sunday, Tuesday through Friday: 1st shift
Performed stat? No
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