Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

PORPHYRINS, FRACTIONATED, QUANTITATIVE,24-HR URINE

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2879         Geisinger Epic ID: 15130

SPECIMEN COLLECTION
Specimen type:
 24-hour urine
Preferred collection container:
Alternate Collection Container:
24-hour urine container (no preservative)
Specimen required:
5 mL aliquot of 24-hour urine, as above; minimum 5 mL.
Special notes:
 Protect specimen from light. Collection with no preservative is acceptable, if properly refrigerated and protected from light. 24-hour total volume must be provided on the test request form.
SPECIMEN PROCESSING
Specimen processing instructions:
Protect from light. 
Transport temperature:
 Refrigerated (preferred) or frozen.
Specimen stability:
 Room Temperature: Unacceptable. Refrigerated: 7 days. Frozen: 1 month.
Rejection criteria:
 Samples received at room temperature. Samples not protected from light. Samples with pH less than 4.
TEST DETAILS
Reference interval:
Adult Reference Ranges  
Uroporphyrin I 4.1-22.4 mcg/24 h
Uroporphyrin III 0.7-7.4 mcg/24 h
Heptacarboxyporphyrin ≤3.3 mcg/24 h
Hexacarboxyporphyrin ≤10 mcg/24 h
Pentacarboxyporphyrin ≤4.6 mcg/24 h
Coproporphyrin I 7.1-48.7 mcg/24 h
Coproporphyrin III 11.0-148.5 mcg/24 h
Total Porphyrins 35-210.7 mcg/24 h
Additional information:
 Patients with hereditary forms of porphyria usually will present with profound elevations of these analytes (> 5-fold) during acute episodes. Moderate elevations (< 3-fold) are more often due to medications or environmental factors.
CPT code(s):
 84120
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
 Uroporphyrin, Heptacarboxylporphyrin, Hexacarboxylporphyrin, Pentacarboxylporphyrin, Coproporphyrin, Total Porphyrins
Methodology:
High Performance Liquid Chromatography (HPLC)
Synonyms:
Quest test code 729, PORPFR
Clinical significance:
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.

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Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Tuesday-Friday morning    
Performed STAT? No
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