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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
LUPUS ANTICOAGULANT PROFILE |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2624 Geisinger Epic ID: 23513 | |
SPECIMEN COLLECTION |
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Specimen type: |
Platelet-free plasma AND serum. | |
Preferred collection container: |
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Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
Three (3) 1 mL aliquots of platelet-free citrated plasma AND one (1) 1 mL aliquot of serum. Freeze all aliquots. | |
Special notes: |
Collect two (2) 2.7 mL blue-top tubes (3.2% sodium citrate) AND one (1) 6 mL red-top tube (non-serum separator). | |
Patient preparation: |
Must be off heparin 48 hours prior to testing; must be off Coumadin 2 weeks prior to testing. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge clotted red-top tube for 15 minutes at 2500 x g, 1 mL aliquot serum, and blue-top tubes at the designated speed and time to obtain platelet-poor plasma (< 10,000/uL). Remove plasma and re-spin the plasma for 10 minutes at 3000 rpm. Remove the supernatant platelet free plasma into three (3) 1 mL aliquots, freeze and transport frozen. | |
Transport temperature: |
Three (3) aliquots of citrated plasma frozen. One (1) aliquot of serum refrigerated. | |
Specimen stability: |
Frozen: -20°C for 30 days, -70°C for 6 months. | |
Rejection criteria: |
Clotted specimen on plasma. Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
See individual test member. | |
CPT code(s): |
85613, 85610, 85730, 86417 x3 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Lupus sensitive APTT (PTT-LA), dilute Russel's viper venom time (DRVVT), beta-2-glycoprotein and anticardiolipin antibodies IgG and IgM. Thrombin time, heparin anti-Xa level, heparin neutralization, LA mixing studies, DRVVT Confirmation and PTT-LA platelet neutralization if indicated. | |
Methodology: |
Mechanical, Chromogenic, and Clot-Based Enzyme Immunoassay (EIA) |
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Synonyms: |
LUPACP, Lupus inhibitor, lupus anticoagulant
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Clinical significance: |
The persistent presence of a lupus anticoagulant in a patient's plasma increases the risk of a thrombotic event. The lupus anticoagulant panel includes a battery of tests to rule out its presence. | |
Doctoral Director(s:) |
Michelle Grant DO | |
| Review Date: | 08/24/2022 | |