Geisinger Medical Laboratories Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB1766             Geisinger Epic ID: 34915

Specimen type:
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
0.5 mL serum; minimum 0.2 mL

Specimen processing instructions:
Allow to clot. Centrifuge and submit 0.5 mL serum. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.
Specimen stability:
Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

Reference interval:
C-ANCA negative, P-ANCA negative.
Interpretation guide:
A sample is considered negative if specific neutrophil staining is equivalent to or less than the negative control well. A sample is considered positive if cytoplasmic or perinuclear staining is observed. If suspicion for C-ANCA or P-ANCA, test progresses to PR3 or MPO, respectively, at an additional charge.
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
C-ANCA, P-ANCA antibody detection.
Indirect Immunofluorescent Antibody (IFA)
ANCA Battery
Anti-neutrophil cytoplasmic antibody
Clinical significance:
The presence of anti-neutrophil antibodies (ANCA) can be used in conjunction with other tests and clinical findings to aid in the assessment of systemic vasculitis. ANCA has classically been divided into C-ANCA and P-ANCA depending on the immunofluorescence pattern observed. C-ANCA is suggestive of Wegener's granulomatosis and, to a lesser degree, microscopic polyarteritis, while P-ANCA has been associated with a more organ-limited vasculitis such as rapidly progressive glomerulonephritis.
Doctoral Director(s:)
Hoi-Ying Elsie Yu PhD, DABCC, FADLM    
Review Date: 12/13/2022

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: Monday-Friday, 1st shift
Performed STAT? No
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