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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
14-3-3 PROTEIN, CSF (PRION DISEASE) |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB3733 Geisinger Epic ID: 145422 | |
SPECIMEN COLLECTION |
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Specimen type: |
CSF | |
Preferred collection container: |
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Specimen required: |
5 mL CSF; minimum 2 mL. | |
Special notes: |
Collect CSF by lumbar puncture. Discard first 2 mL that flows from tap. Collect next 5 mL CSF, avoiding bloody tap. | |
Patient preparation: |
Please complete and send the National Prion Requisition Test Request Form, available on the website at National Prion Disease Pathology Surveillance Center with the sample. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Freeze within 20 minutes of collection. Store and transport frozen. The NPDPSC requests a urine sample for research purposes with all CSF samples if available. Ship Monday through Wednesday. | |
Transport temperature: |
Frozen. | |
Specimen stability: |
Room temperature: 24 hours. Refrigerated: 14 days. Frozen: Indefinitely. | |
TEST DETAILS |
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Additional information: |
Please note: Patient is also asked to submit a frozen urine sample (100-200 mL) for validation of a recently published diagnostic test on Creutzfeldt-Jakob disease; no report will be issued. Please inform patient and/or family that urine is used for research on a diagnostic test and obtain oral consent.
Urine: ship double boxed using a styrofoam container with sufficient dry ice (5 lbs/24 hours).
In addition to our Test Request Form, all senders of CSF will be required to also complete and submit our CSF Billing Requisition Form only if the NPDPSC is to bill patient directly. |
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CPT code(s): |
0035U, 83520 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Real-time quaking-induced conversion (RT-QuIC) Immunoassay |
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Synonyms: |
Quest test code 37989, 14-3-3 Prote
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Clinical significance: |
In CSF: Search for the presence of the 14-3-3 protein. The 14-3-3 protein is a marker for some prion diseases, such as Creutzfeldt-Jakob disease (CJD), when a number of other neurodegenerative conditions are excluded. | |