Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

RHEUMATOID ARTHRITIS DIAGNOSTIC IDENTRA® PANEL 2

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1326         Geisinger Epic ID: 53229

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
3 mL serum; minimum 1.5 mL

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge and aliquot. 
Transport temperature:
Refrigerated (cold packs).
Specimen stability:
Room temperature: 4 days. Refrigerated: 7 days. Frozen: 21 days.
Rejection criteria:
See individual tests.

TEST DETAILS
Additional information:
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
CPT code(s):
86431, 86200, 83520
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Includes Rheumatoid Factor, Cyclic Citrullinated Peptide (CCP) Antibody (IgG), 14-3-3 eta Protein
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
Immunoturbidometric Assay
Synonyms:
Quest test code 91472, RA Diag Pnl2
Clinical significance:
Early diagnosis of rheumatoid arthritis (RA), ie, diagnosis before significant joint erosion occurs, is difficult. Psoriatic arthritis can also be difficult to diagnose clinically early in the disease process, and there are no specific biomarkers. The 14-3-3? (eta) protein is an emerging biomarker for RA and erosive psoriatic arthritis diagnosis. It may play a biologic role in the joint erosive process. Blood levels appear to be elevated in patients with RA, but not in other diseases including psoriasis, osteoporosis, gout, ulcerative colitis, type 1 diabetes, systemic lupus erythematosus, Crohn disease, primary Sjögren syndrome, scleroderma, and multiple sclerosis. The 14-3-3? protein, used in conjunction with rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody, may improve diagnostic sensitivity in the early diagnosis of RA. It may also help differentiate those with psoriatic arthritis joint damage from those without joint damage.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Mon, Wed, Fri a.m.; Report available: 4 days    
Performed stat? No
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