Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

FGF-23 (FIBROBLAST GROWTH FACTOR 23)

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1164         Geisinger Epic ID: 52581

SPECIMEN COLLECTION
Specimen type:
Plasma
Preferred collection container:
Specimen required:
1 mL plasma; minimum 0.3 mL.
Patient preparation:
Fasting specimen is preferred.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge and aliquot. 
Transport temperature:
Frozen.
Specimen stability:
Room temperature: Unacceptable. Refrigerated: 6 hours. Frozen: 90 days.
Rejection criteria:
Received room temperature.

TEST DETAILS
Additional information:
The performance characteristics of this test were determined by Pan Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration.
CPT code(s):
83520
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
Synonyms:
Quest test code 91931, FGF-23 (Fibr)
Clinical significance:
FGF 23 is a major regulator of phosphate homeostasis. It is mainly produced in bone and also in the thymus and brain. Intact FGF 23 is biologically active. High serum FGF 23 levels stimulate FGF 23 expression. It interacts with a specific receptor in renal tubular cells, decreasing the expression of type IIa sodium/phosphate cotransponders and resulting in decreased phosphate reabsorption. FGF reduces the formation of 1, 25 dihydroxy vitamin D resulting in reduced phosphate reabsorption. When FGF 23 levels are pathologically elevated with normal renal function, hypophosphatemia with or without osteomalacia occurs. Measurement of serum FGF 23 can assist in the diagnosis and management of disorders of phosphate and bone metabolism. Human FGF 23 measurement can provide an important diagnostic tool for the laboratory evaluation of patients with a variety of hypo and hyperphosphatemic disorders.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Mon a.m.; Report available: 2-4 days    
Performed stat? No
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