Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

MITOGEN- AND ANTIGEN-INDUCED LYMPHOCYTE PROLIFERATION PANEL

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1058         Geisinger Epic ID: 52157

SPECIMEN COLLECTION
Specimen type:
Whole blood
Preferred collection container:
Specimen required:
20 mL whole blood; minimum 10 mL
Special notes:
Whole blood must be transported at room temperature and delivered to the testing laboratory within 48 hours after collection. Maintain and transport blood at room temperature. Avoid temperatures <15° C and >37°C. In hot weather, it may be necessary to pack the specimen in a container with insulating material around it and place this container inside another one that contains a cold pack (ice pack) and absorbent material. This method will help retain the specimen at ambient temperature. For longitudinal studies, draw specimens at the same time of day to minimize diurnal variation.

SPECIMEN PROCESSING
Specimen processing instructions:
Test available by prior arrangement only. Special sample collection and transportation arrangements must be made prior to ordering the test. Contact your local Customer Service Department and request to speak to someone in Referral Testing Department for specific instructions. 
Transport temperature:
Room temperature.
Specimen stability:
Room temperature: 48 hours. Refrigerated: Unacceptable. Frozen: Unacceptable.
Rejection criteria:
Hemolysis. Received refrigerated. Received frozen. Clotted specimens. Samples collected in lithium heparin tubes.

TEST DETAILS
CPT code(s):
86353 x6
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Phytohemagglutinin (PHA)-induced Lymphocyte Proliferation; Concanavalin A (Con A)-induced Lymphocyte Proliferation; Pokeweed Mitogen (PWM)-induced Lymphocyte Proliferation; Candida-induced Lymphocyte Proliferation; Tetanus-induced Lymphocyte Proliferation; Tuberculin PPD-induced Lymphocyte Proliferation
Methodology:
Cell Culture
Scintillation Counter
Synonyms:
Quest test code 91978, Mitogen Pro, Lymphocyte Stimulation,Antigen-induced Cell Proliferation,Tetanus Toxoid, mitogen/antigen-induced,Mitogen-induced Cell Proliferation,Candida, mitogen/antigen-induced,Tuberculin PPD (TB PPD), mitogen/antigen-induced
Clinical significance:
Measurement of human lymphocytes' proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions. Mitogens, such as plant lectins phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), are able to nonspecifically stimulate lymphocyte proliferation and used to evaluate patient immune responsiveness. Lymphocyte proliferation response to antigens, such as Candida, tetanus toxoid and tuberculin purified protein derivative (PPD), are evaluated as a function of memory in cell-mediated immunity.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Tues-Fri a.m.; Report available: 15 days    
Performed stat? No
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