Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB1039         Geisinger Epic ID: 52081

Specimen type:
Random urine
Preferred collection container:
Specimen required:
5 mL random urine (no preservative); minimum 3 mL
Special notes:
Collect a random urine specimen within a few hours of symptom onset. No preservative.
Patient preparation:
Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.

Transport temperature:
Refrigerated (cold packs).
Specimen stability:
Room temperature: 14 days. Refrigerated: 28 days. Frozen: 28 days.

Additional information:
Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred. See NMH24 /N-Methylhistamine, 24 Hour, Urine.
CPT code(s):
82542, 82570
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Enzymatic Colorimetric
Liquid Chromatography Mass Spectrometry (LC/MS)
Quest test code 39604, N-Methylhist
Clinical significance:
Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions using random urine specimens. Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Tues, Thurs; Report available: 3 days    
Performed STAT? No
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