Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

MYGENVAR HEMATOLOGY GENE PANEL, NEXT GENERATION SEQUENCING

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB3509         Geisinger Epic ID: 66457

SPECIMEN COLLECTION
Specimen type:
Bone Marrow
Preferred collection container:
Specimen required:
3 mL lavender-top K2 EDTA tube
Special notes:
For non-GMC collection sites, collection tube is included in Bone Marrow (BM) collection kit.

SPECIMEN PROCESSING
Specimen processing instructions:
Mix well immediately. Do not centrifuge. 
Transport temperature:
Room temperature, 18-25°C, up to 24 hours. Refrigerated, 2-8°C.
Specimen stability:
Room temperature, 18-25°C, up to 24 hours. Refrigerated, 2-8°C: 7 days. Specimen must be extracted within 7 days.
Rejection criteria:
Wrong collection tube. Improper storage or transport temperature. Stability limits exceeded. Shared or comingled specimens.

TEST DETAILS
Reference interval:
Negative (no mutations detected)
Additional information:
For molecular testing, original tube is required.
CPT code(s):
81455
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
This test is performed by next-generation sequencing of targeted regions of the genes listed: ABL1, ANKRD26, ASXL1, ATRX, BCOR, BCORL1, BRAF, BTK, CALR, CBL, CBLB, CBLC, CCND2, CDC25C, CDKN2A, CEBPA, CSF3R, CUX1, CXCR4, DCK, DDX41, DHX15, DNMT3A, ENTK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, IKZF1, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, LUC7L2, MAP2K1, MPL, MYC, MYD88, NF1, NOTCH1, NPM1, NRAS, PDGFRA, PHF6, PPM1D, PTEN, PTPN11, RAD21, RBBP6, RPS14, RUNX1, SETBP1, SF3B1, SH2B3, SLC29A1, SMC1A, SMC3, SRSF2, STAG2, STAT3, TET2, TP53, U2AF1, U2AF2, WT1, XPO1, and ZRSR2.

Gene

Accession

Target Exon

ABL1

NM_005157

4, 5, 6, 7, 8, 9, 10

ANKRD26

NM_014915

1 (c.-113-c.-134)

ASXL1

NM_015338

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13

ASXL1

NM_001164603

5

ATRX

NM_000489

8, 9, 10, 11, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32

BCOR

NM_017745

2, 3, 4, 5, 6, 7, 9, 10, 11, 12, 13, 14, 15

BCOR

NM_001123385

8

BCORL1

NM_021946

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

BRAF

NM_004333

3, 10, 11, 12, 13, 15

BTK

NM_000061

15

CALR

NM_004343

8, 9

CBL

NM_005188

2, 3, 4, 5, 7, 8, 9, 16

CBLB

NM_170662

3, 9, 10

CBLC

NM_012116

9, 10

CCND2

NM_001759

5

CDKN2A

NM_058197

1

CDKN2A

NM_058195

1

CDKN2A

NM_000077

2, 3

CDKN2A

NM_001195132

3

CEBPA

NM_004364

1

CSF3R

NM_156039

17

CSF3R

NM_172313

10, 18

CSF3R

NM_000760

14, 15, 16

CUX1

NM_001202543

15, 16, 17, 18, 19, 20, 21, 22, 23, 24

CUX1

NM_001913

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 ,23

CUX1

NM_181552

1

CXCR4

NM_003467

1, 2

DCK

NM_000788

2, 3

DDX41

NM_016222

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17

DHX15

NM_001358

3

DNMT3A

NM_022552

2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23

DNMT3A

NM_153759

1,2

DNMT3A

NM_175630

4

ETNK1

NM_018638

3

ETV6

NM_001987

1, 2, 3, 4, 5, 6, 7, 8

EZH2

NM_004456

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20

FBXW7

NM_018315

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

FLT3

NM_004119

8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21

GATA1

NM_002049

2

GATA2

NM_032638

2, 3, 4, 5, 6

GNAS

NM_000516

8, 9, 10, 11

HRAS

NM_005343

2, 3, 4

IDH1

NM_005896

3, 4

IDH2

NM_002168

4, 6

IKZF1

NM_001220769

5

IKZF1

NM_001220767

2, 3, 4, 5, 7

IKZF1

NM_001220771

4

IKZF1

NM_001291845

4

IKZF1

NM_001291847

5

JAK2

NM_004972

12, 13, 14, 15, 16, 19, 20, 21, 22, 23, 24, 25

JAK3

NM_000215

3, 11, 13, 15, 18, 19

KDM6A

NM_021140

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29

KDM6A

NM_001291415

14

KIT

NM_000222

1, 2, 5, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18

KMT2A

NM_005933

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36

KMT2A

NM_001197104

14

KRAS

NM_004985

2, 3, 4

LUC7L2

NM_016019

1, 2, 3, 4, 5, 6, 7, 8, 9, 10

LUC7L2

NM_001244585

2

MAP2K1

NM_002755

2, 3

MPL

NM_005373

10, 12

MYC

NM_002467

1, 2, 3

MYD88

NM_002468

4, 5

MYD88

NM_001172567

3

NF1

NM_000267

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57

NF1

NM_001128147

15

NF1

NM_001042492

31

NOTCH1

NM_017617

26, 27, 28, 34,c.*370 to c.*380

NPM1

NM_002520

12

NRAS

NM_002524

2, 3, 4, 5

PDGFRA

NM_006206

12, 14, 15, 18

PHF6

NM_032335

2, 3, 4,5 ,6, 7, 8

PHF6

NM_001015877

10

PHF6

NM_032458

9

PPM1D

NM_003620

6

PTEN

NM_000314

1, 2, 3, 4, 5, 6, 7, 8, 9

PTPN11

NM_002834

3, 4, 7, 8, 12, 13

PTPN11

NM_080601

11

RAD21

NM_006265

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14

RBBP6

NM_006910

p.1444, p.1451, p.1569, p.1654, p.1673

RUNX1

NM_001754

2, 3, 5, 6, 7, 8, 9

RUNX1

NM_001122607

1, 5

SETBP1

NM_015559

4 (p.799-p.950)

SF3B1

NM_012433

13, 14, 15, 16, 17, 18, 19, 20, 21

SH2B3

NM_005475

2, 3, 4, 5, 6, 7, 8

SLC29A1

NM_001078175

4, 13

SMC1A

NM_006306

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25

SMC1A

NM_001281463

2

SMC3

NM_005445

10, 13, 19, 23, 25, 28

SRSF2

NM_003016

1, 2

STAG2

NM_006603

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33

STAG2

NM_001042749

32

STAT3

NM_003150

20

STAT3

NM_139276

21

TET2

NM_001127208

4, 5, 6, 7, 8, 9, 10, 11

TET2

NM_017628

3

TP53

NM_000546

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

TP53

NM_001276696

10

TP53

NM_001276695

10

U2AF1

NM_006758

2, 6, 7

U2AF1

NM_001025204

6

U2AF2

NM_007279

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

WT1

NM_000378

1, 2, 3, 4, 5, 6, 7, 9

WT1

NM_001198552

8

XPO1

NM_003400

15, 16, 18

ZRSR2

NM_005089

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

Synonyms:
Heme Panel, Heme Gene Panel, Hematology Panel, Hematology Gene Panel, Hematology Mutation Panel, NGS, Next-Generation Sequencing
Clinical significance:
The MyGenVar Hematology Gene Panel targets DNA variants in hematologic neoplasms, sarcomas or solid tumors, by high-throughput sequencing. It helps determine diagnostic classification and provide prognostic or therapeutic information for clinical management.
Doctoral Director(s:)
Yi Ding MD, PhD    
Review Date: 08/17/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Molecular Diagnostics
Technical Lead: Lisa Scicchitano
Frequency: Weekly, on Tuesday
Performed stat? No
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