Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  


Sunquest Test Code:
HLAB58      Geisinger Epic Procedure Code: HLAB58         Geisinger Epic ID: 45036

Specimen type:
Whole blood
Preferred collection container:
Alternate Collection Container:
6 mL pink-top K2 EDTA tube
Specimen required:
3 mL EDTA whole blood

Specimen processing instructions:
Send specimen in original tube 
Transport temperature:
Room temperature
Specimen stability:
Mayo will determine if specimen is suitable

Interpretation guide:
Positivity for HLA-B*5801 confers risk for hypersensitivity to allopurinol
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Allopurinol hypersensitivity
Clinical significance:
Guidelines have been developed by the Clinical Pharmacogenomics Implementation Consortium that recommends that HLA-B*5801 genotyping be performed and that allopurinol should not be prescribed to patients who test positive for the allele. Also, guidelines developed by the 2012 American College of Rheumatology for Management of Gout recommend that HLA-B*5801 testing should be considered in select patient subpopulations at an elevated risk for AHS. Those of Korean descent, especially those with stage 3 or higher chronic kidney disease, or of Han Chinese or Thai extraction irrespective of renal function should be tested. However, given the literature as reviewed above, consideration should be given to testing all patients who will be given allopurinol.

Performing Locations

Mayo Medical Laboratories

Technical Lead: Michael Weaver    
Frequency: Monday, Thursday    
Performed stat? No
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