Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

FISH, MULTIPLE MYELOMA 13q-,17p-,rea 14q32

Sunquest Test Code:

Specimen type:
Bone marrow or whole blood
Preferred collection container:
Alternate Collection Container:
4 mL green/green-top (sodium heparin) tube
Specimen required:
3 mL (min 1 mL) bone marrow in culture transport media or green-top sodium heparin tube OR 5 mL whole blood in sodium heparin green-top tube.
Special notes:
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.

Transport temperature:
Room temperature.
Specimen stability:
Room temperature: Unspecified. Refrigerated: Unspecified. Frozen: Unacceptable.
Rejection criteria:
Frozen specimen.

Interpretation guide:
Interpretive report.
Additional information:
Multiple Myeloma (MM) is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. The most frequent abnormalities with less favorable outcome, 13q-, 14q32 (IGH) rearrangements and 17p- (TP53), have been included in this panel. Three separate microscopic analyses, one for each probe set, are performed on 100 - 300 interphase cells. For initial patient testing, suggest performing this test before FISH, Multiple Myeloma, 5, 9, 15, Test Code 19619.
CPT code(s):
88275 x3, 88271 x4
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
FISH, Multiple Myeloma, 13q-,17p-,rea 14q32
Fluorescence In Situ Hybridization (FISH)
Quest test code 16077
Clinical significance:
Multiple Myeloma (MM) is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. In most cases, there is low proliferation index of terminally different malignant plasma cells. As a result, conventional cytogenetic analysis frequently yields normal results. The most frequent abnormalities with prognostic association have been included in this panel (13q-, 14q rearrangements and 17p-). Interphase FISH studies can enhance the detection rate and complement conventional cytogenetic techniques.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Monday-Saturday afternoon    
Performed stat? No
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